Raycaster/ Eval

Company environment · Oral FDC · NMPA / CDE

A combination tablet under review in China

Under review; answering a formal deficiency notice. Start at the top to see what the company does, then the jobs AI models were given here and how each scored.

1What does this company do?

A drug company seeking approval in China for a tablet that combines two existing medicines.

Combining two known drugs in one tablet still needs full quality evidence and proof it behaves like taking both.

2Where is the product on its way to patients?

The application is under review, and China’s drug evaluation center has sent a list of deficiencies.

  1. 1Discovery
  2. 2Lab & animal studies
  3. 3Human trials
  4. 4Filing & review
    • The product is here
  5. 5Approved
  6. 6On the market

The company has 80 days to answer questions on impurities, manufacturing, dissolution and specifications.

3What is happening right now?

The deficiency notice arrived 31 January 2024; the 80-day clock is running.

Each team drafts its part of the answer from the file as it stands, without leaning on answers that were only written later.

4Which jobs were the models given?

6 jobs, each graded against a specialist’s checklist.

Scores are checks passed out of checks in the list. Each model ran each job once.

JobSolOpusAstra
01Draft the answer showing the tablet’s formula is similar enough to waive a new absorption study.2/85/85/8
02Draft the answers on impurities and test methods, and update the release specification.4/86/86/8
03Draft the answer on controlling a cancer-causing impurity class and update its limits.1/83/85/8
04Draft the answers on ingredient particle size, in-process checks and hold times.4/84/84/8
05Draft the answers on how fast the tablet dissolves and update those limits.2/82/83/8
06Fold a provincial lab’s comments into the specifications for all three strengths.0/80/84/8

5–7Evidence, work and verdict

This company’s files stay private.

It is built from a real product’s records, so its files, runs and checklists aren’t published. To follow a job all the way down to each check, open one of the public environments.

Havenor Therapeutics (fictional, fully published) →
Broad Institute (real, public FDA record) →

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